Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 12, Issue 22, Pages 5785-5789Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.200600026
Keywords
asymmetric synthesis; chirality; kinetic resolution; noninear effects; racemic reagent
Categories
Ask authors/readers for more resources
The reaction of a racemic reagent on a mixture of enantiomers with small ee (ee=enantiomeric excess) has been studied for amine acylation. A substantial asymmetric amplification could be realized, for example, from 67 to > 95.5 ee. The combination of asymmetric amplifications is subsequently discussed. Two sequential asymmetric amplifications, one using a racemic reagent and another using a positive nonlinear effect allowed us to start from 1.5 % ee and end with a large amount of a product of 97 % ee.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available