Highly enantioselective fluorination reactions of β-ketoesters and β-ketophosphonates catalyzed by chiral palladium complexes

Using chiral palladium enolates as key intermediates, efficient catalytic enantioselective fluorination reactions of active methine compounds have been developed. These reactions can be conducted in alcoholic solvents without any precaution to exclude water and moisture, and various beta-ketoesters and beta-ketophosphonates were fluorinated in a highly enantioselective manner (up to 98% ee). (c) 2006 Elsevier Ltd. All rights reserved.