Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 254, Issue -, Pages 91-96Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2006.04.030
Keywords
kisspeptins; gonadotropin-releasing hormone; neuroendocrine reproductive axis
Categories
Funding
- NICHD NIH HHS [U54 HD 12629, R01 HD27142] Funding Source: Medline
- NIDDK NIH HHS [R01 DK61517] Funding Source: Medline
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Kisspeptins. which are products of the Kiss1 gene, and their receptor, GPR54, have emerged as key players in the regulation of gonadotropin-releasing hormone (GnRH) secretion. Mutations or targeted deletions of GPR54 produce isolated hypogonadotropic hypogonadism in humans and mice, indicating that signaling through this receptor is a prerequisite for sexual maturation. Centrally administered kisspeptins stimulate GnRH and Gonadotropin secretion in prepubertal and adult animals. Kisspeptin-expressing neurons are direct targets for the negative and positive feedback actions of sex steroids, which differentially regulate the expression of KiSS-1 mRNA in various regions of the forebrain. This review highlights what is currently known about kisspeptin-GPR54 signaling in the regulation of the neuroendocrine reproductive axis. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
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