Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 49, Issue 15, Pages 4781-4784Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm060389m
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Agonists of peroxisome proliferator-activated receptor gamma (PPAR gamma) are of interest as a treatment for diabetes, which prompted the identification of a new class of non-TZD PPAR gamma agonist. Moreover, compound 14c has displayed the most active agonistic activity with an EC50 value of 50 nM, in addition to exhibiting a new binding mode in the X-ray cocrystal structure.
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