Journal
ANALYTICA CHIMICA ACTA
Volume 573, Issue -, Pages 65-68Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.aca.2006.01.016
Keywords
impedance; biosensor; nanogap; thrombin; protein-interaction
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Nanogap-impedance biosensors with electrode separations of 75 nm have been fabricated by means of standard optical lithography and a sacrificial layer technique. Due to a large surface-to-volume ratio and high sensitivity, these sensors are superior compared to open interdigitated electrode structures. As a model, the blood coagulation factor thrombin was detected. As specific receptors, either an antibody or a RNA-aptamer have been used. The microwave frequency impedance measurements showed that both ligands were equally suitable for the specific detection of thrombin. (c) 2006 Elsevier B.V. All rights reserved.
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