Journal
NEUROREPORT
Volume 17, Issue 11, Pages 1181-1185Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/01.wnr.0000230512.01339.72
Keywords
D-serine; glutamate; L-serine; N-methyl-D-aspartate receptor; Western blot analysis
Categories
Funding
- NIMH NIH HHS [MH45212, MH64673, MH53327] Funding Source: Medline
Ask authors/readers for more resources
Evidence of gluatamatergic dysfunction in schizophrernia associated with the N-methyl-D-aspartate receptor has historically demonstrated changes primarily attributable to neurons. We propose an astrocytic component to N-methyl-D-aspartate receptor dysfunction in this illness. We studied the expression of serine racemadse, an astrocytic enzyme which synthesizes the N-methyl-D-aspartate receptor coagonist D-serine, using Western blot analysis in postmortem hippocampus and cortex in schizophrenia and a comparison group. We found increased expression in the hippocampus in schizophrenia. This is the first study to demonstrate alterations in schizophrenia of an astrocytic enzyme responsible for synthesizing a neuromodulator, and further evidence that astrocytes may play a direct role in N-methyl-aspartate receptor dysfunction in schizophrenia.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available