Journal
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Volume 58, Issue 2, Pages 256-265Publisher
OXFORD UNIV PRESS
DOI: 10.1093/jac/dkl224
Keywords
pharmacokinetics; pharmacodynamics; tetracyclines
Ask authors/readers for more resources
The pharmacokinetics of tetracyclines and glycylcyclines are described in three groups. Group 1, the oldest group, represented by tetracycline, oxytetracycline, chlortetracycline, demeclocycline, lymecycline, methacycline and rolitetracycline is characterized by poor absorption after food. Group 2, represented by doxycycline and minocycline, is more reliably absorbed orally, while group 3, represented by the glycylcycline tigecycline, is injectable only, with an improved antibacterial spectrum compared with the tetracyclines. Though incompletely understood, the pharmacodynamic properties of the tetracyclines and glycylcyclines are summarized.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available