Journal
ANNALS OF INTERNAL MEDICINE
Volume 155, Issue 8, Pages 529-U104Publisher
AMER COLL PHYSICIANS
DOI: 10.7326/0003-4819-155-8-201110180-00009
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Funding
- Medical Research Council as part of the Medical Research Council-National Institute for Health Research
- National Institute for Health Research
- Cancer Research UK
- Netherlands Organization for Scientific Research [916.10.034]
- Medical Research Council [G0800808, G0801405] Funding Source: researchfish
- MRC [G0800808, G0801405] Funding Source: UKRI
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In 2003, the QUADAS tool for systematic reviews of diagnostic accuracy studies was developed. Experience, anecdotal reports, and feedback suggested areas for improvement; therefore, QUADAS-2 was developed. This tool comprises 4 domains: patient selection, index test, reference standard, and flow and timing. Each domain is assessed in terms of risk of bias, and the first 3 domains are also assessed in terms of concerns regarding applicability. Signalling questions are included to help judge risk of bias. The QUADAS-2 tool is applied in 4 phases: summarize the review question, tailor the tool and produce review-specific guidance, construct a flow diagram for the primary study, and judge bias and applicability. This tool will allow for more transparent rating of bias and applicability of primary diagnostic accuracy studies.
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