Journal
EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
Volume 14, Issue 3, Pages 389-401Publisher
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/1064-1297.14.3.389
Keywords
novelty seeking; self-administration; amphetamine; individual differences; locomotor
Funding
- NIDA NIH HHS [P50 DA05312, F32 DA16013] Funding Source: Medline
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These experiments determined whether individual differences in response to novelty subsequently predict the ability of novel stimuli, presented prior to the session, to decrease amphetamine self-administration. Using an inescapable locomotor test, the authors found that high-responder rats (Rattus norvegicus) showed a greater novelty-induced decrease in the acquisition of self-administration compared with low-responder rats. This effect was dose dependent and generalized to sucrose-reinforced responding. Using a free-choice place preference test, the authors found that high-novelty-seeking rats also showed a greater novelty-induced decrease in the acquisition of self-administration compared with low-novelty-seeking rats. Regardless of individual differences, novelty had little effect on amphetamine self-administration during the maintenance phase. These results suggest that exposure to novel environmental stimuli may reduce acquisition of drug-taking behavior, especially among high-novelty-seeking individuals.
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