Journal
BIOCHEMISTRY-MOSCOW
Volume 71, Issue 8, Pages 851-860Publisher
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S0006297906080050
Keywords
parkin; Parkinson's disease; proteasome; ubiquitination; ubiquitin-protein ligase; mitochondria
Categories
Funding
- Wellcome Trust [072381/Z/03/Z] Funding Source: Medline
Ask authors/readers for more resources
Parkin is a protein encoded by the corresponding parkin gene. It exhibits ubiquitin-protein ligase activity. In this review, we analyze domain structure, substrate specificity, subcellular localization of parkin, and regulation of its activity. Then we discuss data on the effects of various mutations in the parkin gene on structure and functions of this protein and results obtained with parkin knock-out animals. Better understanding of parkin biochemistry, its compartmentalization, functions, and altered functions would help the development of new approaches for the treatment of both inherited and sporadic cases of Parkinson's disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available