Journal
ONCOGENE
Volume 25, Issue 34, Pages 4697-4705Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1209596
Keywords
apoptosis; Fis1; CED-9; yeast; aging; virus
Funding
- NCI NIH HHS [R01 CA073581] Funding Source: Medline
- NINDS NIH HHS [R01 NS045876, R01 NS034175, R01 NS037402] Funding Source: Medline
Ask authors/readers for more resources
At least in mammals, we have some understanding of how caspases facilitate mitochondria-mediated cell death, but the biochemical mechanisms by which other factors promote or inhibit programmed cell death are not understood. Moreover, most of these factors are only studied after treating cells with a death stimulus. A growing body of new evidence suggests that cell death regulators also have 'day jobs' in healthy cells. Even caspases, mitochondrial fission proteins and pro-death Bcl-2 family proteins appear to have normal cellular functions that promote cell survival. Here, we review some of the supporting evidence and stretch beyond the evidence to seek an understanding of the remaining questions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available