Journal
NATURE CHEMICAL BIOLOGY
Volume 2, Issue 8, Pages 415-416Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nchembio806
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Funding
- NCRR NIH HHS [RR0052] Funding Source: Medline
- PHS HHS [R01 A145774] Funding Source: Medline
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The high cost and protracted time line of new drug discovery are major roadblocks to creating therapies for neglected diseases. To accelerate drug discovery we created a library of 2,687 existing drugs and screened for inhibitors of the human malaria parasite Plasmodium falciparum. The antihistamine astemizole and its principal human metabolite are promising new inhibitors of chloroquine-sensitive and multidrug-resistant parasites, and they show efficacy in two mouse models of malaria.
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