Journal
DEVELOPMENT
Volume 133, Issue 15, Pages 2793-2804Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.02441
Keywords
roof plate; dorsal midline; signaling center; cerebellum; isthmic organizer; Lmx1a; Bmp; neuronal specification; proliferation; mouse
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Funding
- NINDS NIH HHS [R01 NS044262] Funding Source: Medline
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During embryogenesis, the isthmic organizer, a well-described signaling center at the junction of the mid-hindbrain, establishes the cerebellar territory along the anterior/posterior axis of the neural tube. Mechanisms specifying distinct populations within the early cerebellar anlage are less defined. Using a newly developed gene expression map of the early cerebellar anlage, we demonstrate that secreted signals from the rhombomere 1 roof plate are both necessary and sufficient for specification of the adjacent cerebellar rhombic lip and its derivative fates. Surprisingly, we show that the roof plate is not absolutely required for initial specification of more distal cerebellar cell fates, but rather regulates progenitor proliferation and cell position within the cerebellar anlage. Thus, in addition to the isthmus, the roof plate represents an important signaling center controlling multiple aspects of cerebellar patterning.
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