Journal
GLYCOBIOLOGY
Volume 16, Issue 8, Pages 1C-7CPublisher
OXFORD UNIV PRESS INC
DOI: 10.1093/glycob/cwj126
Keywords
asialoglycoprotein receptor; glycan array; Kupffer cell receptor; lectin; scavenger receptor
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Funding
- NIGMS NIH HHS [GM62116, U54 GM062116] Funding Source: Medline
- Wellcome Trust [075565] Funding Source: Medline
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Profiling of the four known galactose-binding receptors in the C-type lectin family has been undertaken in parallel on a glycan array. The results are generally consistent with those of previous assays using various different formats, but they provide a direct comparison of the properties of the four receptors, revealing that they fall into two distinct groups. The major subunit of the rat asialoglycoprotein receptor and the rat Kupffer cell receptor show similar broad preferences for GaINAc-terminated glycans, while the rat macrophage galactose lectin and the human scavenger receptor C-type lectin (SRCL) bind more restricted sets of glycans. Both of these receptors bind to Lewis x-type structures, but the macrophage galactose lectin also interacts strongly with biantennary galactose- and GaINAc-terminated glycans. Although the similar glycan-binding profiles for the asialoglycoprotein receptor and the Kupffer cell receptor might suggest that these receptors are functionally redundant, analysis of fibroblasts transfected with full-length Kupffer cell receptor reveals that they fail to endocytose glycosylated ligand.
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