Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 7, Issue 8, Pages 580-588Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm1982
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As genetic material DNA is wonderful, but as a macromolecule it is unruly, voluminous and fragile. Without the action of DNA replicases, topoisomerases, helicases, translocases and recombinases, the genome would collapse into a topologically entangled random coil that would be useless to the cell. We discuss the organization, movement and energetics of these proteins that are crucial to the preservation of a molecule that has such beautiful biological but challenging physical properties.
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