Journal
SEMINARS IN CANCER BIOLOGY
Volume 16, Issue 4, Pages 242-252Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2006.08.001
Keywords
Myc; transcription; chromatin; acetyltransferase; polymerase; proliferation; oncogenesis; cancer; cofactor
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Funding
- Medical Research Council [G0700240] Funding Source: Medline
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The Myc family proteins are potent oncogenes that can activate and repress a very large number of cellular target genes. The amino terminus of Myc contains a transactivation domain that can recruit a number of nuclear cofactors with diverse activities. Functional studies link transactivation to the ability of Myc to promote normal cell proliferation and for oncogenic transformation. The biochemical mechanism of Myc-mediated transactivation has revealed a wide range of effects on chromatin and basal transcription. This review summarizes recent advances in understanding the function of Myc as a transcriptional activator and the role of this activity in Myc biological activities. (c) 2006 Elsevier Ltd. All rights reserved.
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