Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 56, Issue 2, Pages 386-394Publisher
WILEY
DOI: 10.1002/mrm.20946
Keywords
water T-1/T-2 relaxation; metabolite T-1/T-2 relaxation; macromolecular T-1/T-2 relaxation; high-field NMR; sensitivity; spectral resolution; brain
Funding
- NIBIB NIH HHS [R01 EB002097] Funding Source: Medline
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Comprehensive and quantitative measurements of T-1 and T-2 relaxation times of water, metabolites, and macromolecules in rat brain under similar experimental conditions at three high magnetic field strengths (4.0 T, 9.4 T, and 11.7 T) are presented. Water relaxation showed a highly significant increase (T,) and decrease (T-2) with increasing field strength for all nine analyzed brain structures. Similar but less pronounced effects were observed for all metabolites. Macromolecules displayed field-independent T2 relaxation and a strong increase of T, with field strength. Among other features, these data show that while spectral resolution continues to increase with field strength, the absolute signal-to-noise ratio (SNR) in T-1/T-2-based anatomical MRI quickly levels off beyond similar to 7 T and may actually decrease at higher magnetic fields.
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