Journal
ENDOCRINE
Volume 30, Issue 1, Pages 19-26Publisher
SPRINGER
DOI: 10.1385/ENDO:30:1:19
Keywords
insulin resistance; familial studies; association studies; linkage; obesity
Categories
Funding
- NCRR NIH HHS [M01 RR10732] Funding Source: Medline
- NICHD NIH HHS [K24 HD01476, U54 HD34449] Funding Source: Medline
Ask authors/readers for more resources
Both genes and the environment contribute to PCOS. Obesity, exacerbated by poor dietary choices and physical inactivity, worsens PCOS in susceptible individuals. The role of other environmental modifiers such as infectious agents or toxins are speculative. Phenotype confusion has characterized genetic studies of PCOS. Although several loci have been proposed as PCOS genes including CYP11A, the insulin gene, the follistatin gene, and a region near the insulin receptor, the evidence supporting linkage is not overwhelming. The strongest case can be made for the region near the insulin receptor gene (but not involving this gene), as it has been identified in two separate studies, and perhaps most importantly has not yet been refuted by larger studies. However, the responsible gene at chromosome 19p13.3 remains to be identified. To date, no gene has been identified that causes or contributes substantially to the development of a PCOS phenotype.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available