Journal
CURRENT OPINION IN PLANT BIOLOGY
Volume 9, Issue 4, Pages 376-382Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.pbi.2006.05.005
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Funding
- NIGMS NIH HHS [R01 GM066025] Funding Source: Medline
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Bacterial pathogens have co-evolved with their hosts in their ongoing quest for advantage in the resulting interaction. These intimate associations have resulted in remarkable adaptations of prokaryotic virulence proteins and their eukaryotic molecular targets. An important strategy used by microbial pathogens of animals to manipulate host cellular functions is structural mimicry of eukaryotic proteins. Recent evidence demonstrates that plant pathogens also use structural mimicry of host factors as a virulence strategy. Nearly all virulence proteins from phytopathogenic bacteria have eluded functional annotation on the basis of primary amino-acid sequence. Recent efforts to determine their three-dimensional structures are, however, revealing important clues about the mechanisms of bacterial virulence in plants.
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