Journal
JOURNAL OF VETERINARY MEDICINE SERIES B-INFECTIOUS DISEASES AND VETERINARY PUBLIC HEALTH
Volume 53, Issue 6, Pages 251-256Publisher
WILEY
DOI: 10.1111/j.1439-0450.2006.00966.x
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The prion theory postulates that prions are novel infectious agents that are composed largely, if not entirely, of abnormally folded host-encoded prion proteins. However, the existence of different prion strains is enigma, if these novel infectious agents lack a genetic element, such as a nucleic acid. The best proof for this 'protein-only' concept would be the in vitro generation of prions from synthetic sources. Indeed, a substantial body of evidence has meanwhile been accumulated in favour of this postulate. This mini review recapitulates all relevant studies and experimental data on the generation of synthetic prions.
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