Journal
IMMUNOLOGICAL INVESTIGATIONS
Volume 35, Issue 3-4, Pages 459-483Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/08820130600803429
Keywords
dendritic cells; dysfunction; microenvironment tumor
Categories
Funding
- NCI NIH HHS [R01 CA084488-08, R01 CA100062, R01 CA100062-03, R01 CA084488] Funding Source: Medline
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The fact that the immune response to cancer is compromised has been convincingly demonstrated in murine tumor models as well as in cancer patients. The unresponsiveness of the host immune system is one of the major mechanisms of tumor escape as well as an important factor that limits the success of cancer immunotherapy. Inadequate function of professional antigen presenting cells dendritic cells (DC) in cancer is one of the major elements of compromised anti-tumor immune response. Despite substantial progress in recent years, the mechanism of inadequate DC function in cancer still remains unclear. The tumor microenvironment has emerged as an important component contributing to DC malfunction. In this review we will discuss the potential role of tumor microenvironment in DC dysfunction.
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