Journal
EXPERIMENTAL PARASITOLOGY
Volume 113, Issue 4, Pages 272-275Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.exppara.2006.01.006
Keywords
Taenia solium; Taenia ovis; Taenia saginanta; Echinococcus granulosus; cestode; cysticercosis; parasite; vaccine; gene; oncosphere; expression; PCR; RT-PCR; cDNA; DNA; mRNA
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Funding
- Wellcome Trust Funding Source: Medline
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Recombinant antigens that have been cloned from Taenia solium and Taenia ovis have been shown to be highly effective when used as vaccines against cysticercosis in the intermediate hosts. This study investigated the presence of mRNA encoding the TSOL18 and TSOL16 antigens in different life-cycle stages of T. solium, and their related homologues in T. ovis. Reverse transcription-PCR and Southern blotting demonstrated that the antigens are stage-specifically expressed in the oncosphere. The apparent absence of expression of TSOL18 in the metacestode life-cycle stage suggests that the vaccine based on this antigen targets exclusively the early stages in the development of the parasite. (c) 2006 Elsevier Inc. All rights reserved.
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