Journal
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Volume 17, Issue 6, Pages 251-258Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2006.06.006
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Funding
- NHLBI NIH HHS [R01 HL063282, HL 776611, R01 HL036634, HL 36634, HL 63282] Funding Source: Medline
- NIDDK NIH HHS [R01 DK073120, DK 73120] Funding Source: Medline
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Recent studies have demonstrated key roles for several membrane guanylyl cyclase receptors in the regulation of cell hyperplasia, hypertrophy, migration and extracellular matrix production, all of which having an impact on clinically relevant diseases, including tissue remodeling after injury. Additionally, cell differentiation, and even tumor progression, can be profoundly influenced by one or more of these receptors. Some of these receptors also mediate important communication between the heart and intestine, and the kidney to regulate blood volume and Na+ balance.
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