Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 50, Issue 8, Pages 2836-2841Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00295-06
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Funding
- NIAID NIH HHS [AI51688, AI37856, R01 AI037856, AI36973, AI43846, R01 AI036973, R01 AI051668, R01 AI043846] Funding Source: Medline
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The seven Mycobacterium tuberculosis whiB-like genes encode small proteins postulated to be transcriptional regulators. A systematic real-time reverse transcription-PCR analysis following exposure to antibiotics and a variety of growth and in vitro stress conditions indicates differential, and in some cases dramatic, transcription modulations for the different M. tuberculosis whiB family members. This information together with biochemical analyses of the whiB1 to whiB7 gene products will be important for understanding the biology of this novel family of proteins in mycobacteria and related actinomycetes.
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