Journal
MECHANISMS OF AGEING AND DEVELOPMENT
Volume 127, Issue 8, Pages 653-657Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mad.2006.03.002
Keywords
lipid peroxidation; membranes; docosahexaenoic acid; maximum lifespan
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Funding
- NIA NIH HHS [R01 AG022891, U19 AG023122, AG023122, R01 AG022891-01] Funding Source: Medline
- NIGMS NIH HHS [S06-GM08168, S06 GM008168] Funding Source: Medline
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Two lines of mice, Idaho (Id) and Majuro (Ma), both derived from wild-trapped progenitors, have previously been shown to have extended lifespans in captivity when compared to a genetically heterogenous laboratory line of mice (DC). We have examined whether membrane fatty composition varies with lifespan within the species Mus musculus in a similar manner to that previously demonstrated between mammal species. Muscle and liver phospholipids from these long-living mice lines have a reduced amount of the highly polyunsaturated omega-3 docosahexaenoic acid compared to the DC mice, and consequently their membranes are less likely to peroxidative damage. The relationship between maximum longevity and membrane peroxidation index is similar for these mice lines as previously observed for mammals in general. It is suggested that peroxidation-resistant membranes may be an important component of extended longevity. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
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