Journal
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
Volume 49, Issue 9, Pages 811-815Publisher
JOHN WILEY & SONS LTD
DOI: 10.1002/jlcr.1097
Keywords
positron emission tomography; F-18; 2-[F-18]fluoroadenosine; cancer; adenylate metabolism
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2-[F-18]fluoroadenosine (2-[F-18]FAD), a potential radioligand for assessment of adenylate metabolism, was synthesized by carrier-added and no-carrier-added procedures via nucleophilic radiofluorination of 2-fluoroadenosine and 2-iodoadenosine. The radiochemical yield, specific radioactivity and radiochemical purity of carrier-added and no-carrier-added 2-[F-18]FAD were 5%, 22-30 mCi/mu mol and 99%, and 0.5%, 1200-1700 mCi/mu mol and 99%, respectively. Copyright (c) 2006 John Wiley & Sons, Ltd.
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