Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 50, Issue 8, Pages 2892-2894Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00349-06
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Funding
- NIAID NIH HHS [R01 AI047718, AI054289, R03 AI054289, AI47718] Funding Source: Medline
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A recognized hotspot for mutations conferring reduced echinocandin susceptibility (RES) is residue S645 of Candida albicans Gsc1(Fks1). We report that the mutation F641Y is associated with RES in a C albicans isolate. The analogous Fks2 residue is mutated F to V in a Candida glabrata RES isolate; the introduction of this mutation into susceptible C glabrata confirmed its role in RES. Y641-equivalent Fks residues were identified in intrinsically RES Fusarium species and Candida guilliermondii.
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