Journal
DRUG DISCOVERY TODAY
Volume 11, Issue 15-16, Pages 741-748Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2006.06.016
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Hit discovery technologies range from traditional high-throughput screening to affinity selection of large libraries, fragment-based techniques and computer-aided de novo design, many of which have been extensively reviewed. Development of quality leads using hit confirmation and hit-to-lead approaches present their own challenges, depending on the hit discovery method used to identify the initial hits. In this paper, we summarize common industry practices adopted to tackle hit-to-lead challenges and review how the advantages and drawbacks of different hit discovery techniques could affect the various issues hit-to-lead groups face.
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