Journal
DEVELOPMENTAL CELL
Volume 11, Issue 2, Pages 181-190Publisher
CELL PRESS
DOI: 10.1016/j.devcel.2006.05.014
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Funding
- NCI NIH HHS [CA60538, R01 CA78711, R01 CA078711] Funding Source: Medline
- NICHD NIH HHS [K12-HD00850, K08 HD047674, HD047674, K12 HD000850] Funding Source: Medline
- NIDCR NIH HHS [R01 DE017744, R01 DE017744-01] Funding Source: Medline
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Unlike humans, who have a continuous row of teeth, mice have only molars and incisors separated by a toothless region called a diastema. Although tooth buds form in the embryonic diastema, they regress and do not develop into teeth. Here, we identify members of the Sprouty (Spry) family, which encode negative feedback regulators of fibroblast growth factor (FGF) and other receptor tyrosine kinase signaling, as genes that repress diastema tooth development. We show that different Sprouty genes are deployed in different tissue compartments-Spry2 in epithelium and Spry4 in mesenchyme-to prevent diastema tooth formation. We provide genetic evidence that they function to ensure that diastema tooth buds are refractory to signaling via FGF ligands that are present in the region and thus prevent these buds from engaging in the FGF-mediated bidirectional signaling between epithelium and mesenchyme that normally sustains tooth development.
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