Journal
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Volume 58, Issue 2, Pages 439-443Publisher
OXFORD UNIV PRESS
DOI: 10.1093/jac/dkl220
Keywords
periodontitis; periodontopathogens; bacterial colonization; biofilms
Ask authors/readers for more resources
Background: Porphyromonas gingivalis is a major aetiological agent of periodontitis, a destructive disease affecting the tooth-supporting tissues. Recent reports have indicated that high-molecular-weight molecules from cranberry juice concentrate can prevent the attachment of human pathogens to host tissues. Objectives: The aim of the present study was to investigate the effect of non-dialysable material (NDM) prepared from cranberry juice concentrate on growth, blofilm formation and adherence properties of P. gingivalis. Methods: The effect of cranberry NDM on biofilm formation was studied using a polystyrene microplate assay and by scanning electron microscopy. The effect of cranberry NDM on the attachment properties of P. gingivalis was evaluated by a microplate assay in which mammalian proteins were immobilized into wells. Results: Our results indicated that cranberry NDM is a potent inhibitor of biofilm formation by P. gingivalis. However, it has no effect on growth and viability of bacteria. Cranberry NDM also prevented significantly the attachment of A gingivalis to surfaces coated with type I collagen, fibrinogen or human serum. Conclusions: Our data suggest that cranberry constituents may have a beneficial effect for the prevention and treatment of periodontitis by reducing the capacity of A gingivalis to colonize periodontal sites.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available