Journal
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
Volume 1757, Issue 8, Pages 1012-1018Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbabio.2005.11.003
Keywords
bacteriorhodopsin; retinal; X-ray structure; proton release; proton uptake; hydrogen-bonded chain
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The steps in the mechanism of proton transport in bacteriorhodopsin include examples for most kinds of proton transfer reactions that might occur in a transmembrane pump: proton transfer via a bridging water molecule, coupled protonation/deprotonation of two buried groups separated by a considerable distance, long-range proton migration over a hydrogen-bonded aqueous chain, and capture as well as release of protons at the membrane-water interface. The conceptual and technical advantages of this system have allowed close examination of many of these model reactions, some at an atomic level. (c) 2005 Elsevier B.V. All rights reserved.
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