Journal
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
Volume 195, Issue 2, Pages 415-420Publisher
MOSBY, INC
DOI: 10.1016/j.ajog.2005.12.059
Keywords
leiomyoma; fibroids; keloid; microarray; extracellular matrix; collagen
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Funding
- Intramural NIH HHS [Z99 HD999999] Funding Source: Medline
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This article will discuss some recent insights based on our microarray studies that have emphasized the role the extracellular matrix, transforming growth factor beta, and collagen structure in fibroid formation. These studies led to appreciation of molecular similarities between fibroids and keloids. Collectively, these observations suggest a model of fibroid development based on an abnormal response to tissue repair, resulting in disordered healing and formation of an altered extracellular matrix. (c) 2006 Mosby, Inc. All rights reserved.
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