Journal
NATURE REVIEWS IMMUNOLOGY
Volume 6, Issue 8, Pages 618-623Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nri1866
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The immune system has evolved by continuously increasing its complexity to provide the host with an advantage over infectious agents. The development of immunological memory engenders long-lasting protection and lengthens the lifespan of the host. The generation of subsets of memory T cells with distinct homing and functional properties increases our defensive capabilities. However, the developmental relationship of memory T-cell subsets is a matter of debate. In this Opinion article, in light of recent developments, we suggest that it is probable that two distinct lineages comprise the memory CD8(+) T-cell population generated in response to infection.
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