Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 63, Issue 16, Pages 1833-1849Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-006-6061-3
Keywords
synapse formation; cell adhesion molecule; neuroligin; neurexin; scaffolding protein
Categories
Ask authors/readers for more resources
Proper brain connectivity and neuronal transmission rely on the accurate assembly of neurotransmitter receptors, cell adhesion molecules and several other scaffolding and signaling proteins at synapses. Several new exciting findings point to an important role for the neuroligin family of adhesion molecules in synapse development and function. In this review, we summarize current knowledge of the structure of neuroligins and neurexins, their potential binding partners at the synapse. We also discuss their potential involvement in several aspects of synapse development, including induction, specificity and stabilization. The implication of neuroligins in cognitive disorders such as autism and mental retardation is also discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available