Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 16, Issue 4, Pages 426-432Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2006.06.013
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Funding
- NICHD NIH HHS [R37HD32443, R37 HD032443] Funding Source: Medline
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The hands and feet of a newborn baby are a beautiful reminder of the complexity of embryonic patterning. Classical studies on how these structures form have led to a theoretical framework for understanding, in general, how discrete groups of cells can instruct differential fates across a wider field through the action of long-range signals. The discovery just more than a decade ago that localized expression of Sonic hedgehog (Shh) differentially patterns structures across the limb field, resulting in digits with unique characteristics, provided a starting point for readdressing these models at a molecular level. Current research has revealed unexpected complexity in how a gradient of Shh activity is both established and received, prompting re-evaluation of the nature of patterning mechanisms within the limb.
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