Journal
JOURNAL OF INORGANIC BIOCHEMISTRY
Volume 100, Issue 8, Pages 1314-1319Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2006.03.005
Keywords
DNA interaction; Ru complexes; groove binding
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The interaction with duplex DNA of a series of 12 previously synthesised ruthenium (II) complexes incorporating extended terpyridines or analogous ligands is reported. The interaction was investigated using absorption spectroscopy and also, when possible, luminescence spectroscopy. Binding parameters for the interactions were estimated using established models. It was found that binding affinities are relatively large and their magnitude is somewhat dependent on the metal centre attached to the ligand. Viscosity studies reveal that all the complexes interact with DNA through groove binding and not intercalation. The variation in binding affinities of these complexes is rationalised by a consideration of electrostatic and steric factors. (c) 2006 Elsevier Inc. All rights reserved.
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