Journal
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE
Volume 100, Issue 8, Pages 791-794Publisher
OXFORD UNIV PRESS
DOI: 10.1016/j.trstmh.2005.10.016
Keywords
intestinal permeability; iron; multi-micro nutrients; Ascaris lumbricoides; geophagy; schoolchildren; Zambia
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Elevated intestinal permeability, measured as an increased lactulose:mannitol (L:M) ratio, indicates injury of the small intestinal mucosa. As part of a randomized iron-and multi-micronutrient (without iron) supplementation trial (Nchito et at., 2004), we determined intestinal permeability in a subgroup of schoolchildren at 10 months' follow-up to assess the effect of the interventions. Among 153 children (mean age 10.2 years and 53.6% girls) iron supplementation resulted in a higher L:M ratio compared with placebo (0.29 vs. 0.21, P=0.025). There was no effect of multi-micronutrient supplementation, and no interaction between the interventions. The finding could be one of the mechanisms explaining the negative effects of medicinal. iron supplementation on morbidity found in some other studies. (C) 2005 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.
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