Journal
ANNALS OF HUMAN BIOLOGY
Volume 38, Issue 2, Pages 194-202Publisher
INFORMA HEALTHCARE
DOI: 10.3109/03014460.2010.507221
Keywords
Body height; body mass index; insulin-like growth factor I; insulin-like growth factor binding proteins; obesity
Funding
- US National Cancer Institute [U01 CA098216-01]
- World Cancer Research Fund
- MRC [MC_U105630924] Funding Source: UKRI
- Medical Research Council [G1000143, MC_U105630924, G0401527] Funding Source: researchfish
- Associazione Italiana per la Ricerca sul Cancro Funding Source: Custom
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Background: Height and BMI are risk factors for several types of cancer and may be related to circulating concentrations of insulin-like growth factor-I (IGF-I), a peptide associated with increased cancer risk. Aim: To assess the associations between height, BMI and serum concentrations of IGF-I and IGF binding protein (IGFBP)-1, -2 and -3. Subjects and methods: This cross-sectional analysis included 1142 men and 3589 women aged 32-77 years from the multi-centre study, the European Prospective Investigation of Cancer and Nutrition (EPIC). Results: In men, there was a positive association between height and IGF-I; each 10 cm increment in height was associated with an increase in IGF-I concentrations of 4.3% (95% confidence interval (CI): 1.3-7.5%, p for trend = 0.005), but this association was not statistically significant for women (0.9%, 95% CI: -0.7 to 2.6%, p for trend = 0.264). In both men and women, the association between IGF-I and BMI was non-linear and those with a BMI of 26-27 kg/m(2) had the highest IGF-I concentration. BMI was strongly inversely related to concentrations of IGFBP-1 and IGFBP-2 in men and in women (p for trend for all < 0.001). Conclusion: Height and BMI are associated with IGF-I and its binding proteins, which may be mechanisms through which body size contributes to increased risk of several cancers.
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