Journal
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
Volume 1758, Issue 8, Pages 1117-1125Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamem.2006.03.004
Keywords
PKA phosphorylation; channel protein; Rho; cytoskeleton; vasopressin
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Trafficking of water channel aquaporin-2 (AQP2) to the apical membrane is critical to water reabsorption in renal collecting ducts and its regulation maintains body water homeostasis. However, exact molecular mechanisms which recruit AQP2 are unknown. Recent studies highlighted a key role for spatial and temporal regulation of actin dynamics in AQP2 trafficking. We have recently identified AQP2-binding proteins which directly regulate this trafficking: SPA-1, a GTPase-activating protein (GAP) for Rapt, and cytoskeletal protein actin. In addition, a multiprotein force generator complex which directly binds to AQP2 has been discovered. This review summarizes recent advances related to the mechanism for AQP2 trafficking. (c) 2006 Elsevier B.V. All rights reserved.
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