Journal
EXPERT OPINION ON THERAPEUTIC TARGETS
Volume 10, Issue 4, Pages 573-581Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1517/14728222.10.4.573
Keywords
adiponectin; anti-inflammatory; cardioprotection; myocardial infarction
Categories
Funding
- NHLBI NIH HHS [HL81587, P01 HL081587-02, HL77774, R01 HL077774-02, R01 HL077774, P01 HL081587] Funding Source: Medline
- NIAMS NIH HHS [R01 AR040197-14, R01 AR040197, AR40197] Funding Source: Medline
- NIA NIH HHS [AG15052, R01 AG015052-02, R01 AG015052] Funding Source: Medline
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Adiponectin is an adipose tissue-derived plasma protein which has a reduced concentration in subjects with obesity-related diseases. Adiponectin has antidiabetic and anti-inflammatory characteristics, which lead to beneficial actions on various obesity-linked complications. Recent experimental findings have shown that adiponectin contributes to protection against cardiac remodelling after pressure overload and cardiac injury following ischaemia-reperfusion. Thus, adiponectin could emerge as a potential cardioprotective agent for the treatment of several pathological heart conditions.
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