Journal
NATURE IMMUNOLOGY
Volume 7, Issue 8, Pages 827-834Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni1365
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Funding
- NHLBI NIH HHS [P01 HL056949] Funding Source: Medline
- NIAID NIH HHS [AI49470] Funding Source: Medline
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The migration of B cells into secondary lymphoid organs is required for the generation of an effective immune response. Here we analyzed the involvement of SWAP-70, a Rac-interacting protein involved in actin rearrangement, in B cell entry into lymph nodes. We noted reduced migration of Swap70(-/-) B cells into lymph nodes in vivo. Swap70(-/-) B cells rolled and adhered, yet accumulated in lymph node high endothelial venules. This defect was not due to impaired integrin expression or chemotaxis. Instead, Swap70(-/-) B cells aberrantly regulated integrin-mediated adhesion. During attachment, Swap70(-/-) B cells showed defective polarization and did not form uropods or stabilize lamellipodia at a defined region. Thus, SWAP-70 selectively regulates processes essential for B cell entry into lymph nodes.
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