Journal
PLOS PATHOGENS
Volume 2, Issue 8, Pages 741-745Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.ppat.0020079
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Funding
- MRC [G0401569, G9800943] Funding Source: UKRI
- Medical Research Council [G9800943, G0401569] Funding Source: researchfish
- Intramural NIH HHS Funding Source: Medline
- Medical Research Council [G0401569, G9800943] Funding Source: Medline
- NCI NIH HHS [N01-CO-12400, N01CO12400] Funding Source: Medline
- NIDA NIH HHS [DA04334, R56 DA004334, R37 DA004334, R01 DA004334] Funding Source: Medline
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The compound genotype KIR3DS1/HLA-B Bw4-80I, which presumably favors natural killer cell activation, has been implicated in protection against HIV disease. We show that this genotype confers dual protection over the course of HIV disease; early direct containment of HIV viral load, and late specific defense against opportunistic infections, but not AIDS-related malignancies. The double protection of KIR3DS1/Bw4-80I in an etiologically complex disease such as AIDS, along with the disease specificity of its effects is conceptually novel and underscores the intricacy of host immunogenetics against HIV/AIDS.
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