Journal
TRENDS IN GENETICS
Volume 22, Issue 8, Pages 412-416Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2006.06.004
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The sequences of proteins change at dramatically different rates. Unraveling the association between this variability and cellular and ecological processes will enable a better understanding of protein function and evolution. Although weak associations of protein evolutionary rates with a plethora of variables have been reported, none withstands comparison with the effect of expression levels. A recent report by Drummond et al. suggests that the dominant role of expression levels in slowing the rate of protein evolution stems from selection for translation robustness.
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