Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 63, Issue 16, Pages 1823-1832Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-005-5587-0
Keywords
adaptor; cancer; clathrin; dynamin; endocytosis; mitosis; TIRFM
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Funding
- Medical Research Council [U.1051.02.006(78794), MC_U105178794] Funding Source: Medline
- Medical Research Council [MC_U105178794] Funding Source: researchfish
- MRC [MC_U105178794] Funding Source: UKRI
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Membranes and proteins are moved around the cell in small vesicles. A protein coat aids the budding of such vesicles from donor membranes. The major type of coat used by the cell is composed of clathrin, a three-legged protein that can form lattice-like coats on membranes destined for trafficking. In this review, I outline what we know about clathrin and discuss some recent advances in understanding the basic biology of this fascinating molecule, which include building a molecular model of a clathrin lattice and discovery of a new function for clathrin that occurs during mitosis.
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