Journal
IMMUNOLOGICAL REVIEWS
Volume 212, Issue -, Pages 287-300Publisher
WILEY
DOI: 10.1111/j.0105-2896.2006.00409.x
Keywords
immunity; parasite; regulatory T cells
Categories
Funding
- Intramural NIH HHS Funding Source: Medline
Ask authors/readers for more resources
This review discusses the roles played by natural CD4(+)CD25(+) regulatory T cells (natural Tregs) during parasitic infections. Natural Tregs may limit the magnitude of effector responses, which may result in failure to adequately control infection. However, natural Tregs also help to limit collateral tissue damage caused by vigorous antimicrobial immune responses. We discuss the hypothesis that parasites have evolved means to manipulate the host's natural Treg population, thereby generating conditions that secure survival in their vertebrate host for an extended period of time.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available