4.3 Review

Recent advances (1995-2005) in fluorinated pharmaceuticals based on natural products

Journal

JOURNAL OF FLUORINE CHEMISTRY
Volume 127, Issue 8, Pages 992-1012

Publisher

ELSEVIER SCIENCE SA
DOI: 10.1016/j.jfluchem.2006.05.006

Keywords

fluorinated compounds; fluoro substituent; pharmaceuticals; anti-cancer agents; natural products; drugs; anti-parasitic agents; fluorosteroids

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This present report is devoted to the recent advances, in these last 10 years, in fluorinated analogues of natural products developed as pharmaceuticals, marketed, registered or in clinical development. These mainly concern fluorine-substituted nucleosides, alkaloids, macrolides, steroids, amino acids and prostaglandins. (c) 2006 Elsevier B.V. All rights reserved.

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