A pre-synaptic to-do list for coupling exocytosis to endocytosis

Synaptic vesicles are made locally in the nerve terminal during recycling of membrane. Synaptic vesicle proteins must be sorted and concentrated on the plasma membrane, packaged into a budding vesicle of precise size and cut away from the synaptic surface. Adaptors, scaffolds, BAR-domain and ENTH-domain proteins all must be coordinated to carry out this sequence of events prior to the action of dynamin. Details of how this is orchestrated at nerve terminals are just beginning to emerge.