Journal
JOURNAL OF PSYCHIATRIC RESEARCH
Volume 40, Issue 5, Pages 419-427Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jpsychires.2005.08.011
Keywords
neuroimaging; borderline personality disorder; prefrontal cortex; amygdala
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Funding
- NCRR NIH HHS [S10 RR016917-01, S10 RR016917] Funding Source: Medline
- NIMH NIH HHS [K24 MH076955, T32 MH067547-05, R01 MH056120, T32 MH067547, K24 MH076955-05, R01 MH056120-12] Funding Source: Medline
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Neuroimaging has become one of the most important methods in the investigation of the neurobiological underpinnings of borderline personality disorder. Structural and functional imaging studies have revealed dysfunction in different brain regions which seem to contribute to borderline symptomatology. This review presents relevant studies using different methodologies: volumetry of limbic and prefrontal regions, investigations of brain metabolism under resting conditions, studies of serotonergic neurotransmission, and challenge studies using emotional, stressful, and sensory stimuli. Dysfunction in a frontolimbic network is suggested to mediate much, if not all of the borderline symptomatology. (c) 2005 Elsevier Ltd. All rights reserved.
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