Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 13, Issue 8, Pages 748-750Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb1124
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Funding
- NIGMS NIH HHS [GM051290] Funding Source: Medline
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Synaptic transmission relies on an exquisitely orchestrated series of protein-protein interactions. Here we show that fusion driven by neuronal SNAREs is inhibited by the regulatory protein complexin. Furthermore, inner-leaflet mixing is strongly impaired relative to total lipid mixing, indicating that inhibition by complexin arrests fusion at hemifusion. When the calcium sensor synaptotagmin is added in the presence of calcium, inhibition by complexin is relieved and full fusion rapidly proceeds.
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