Journal
TRENDS IN CARDIOVASCULAR MEDICINE
Volume 16, Issue 6, Pages 204-208Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcm.2006.04.001
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- NHLBI NIH HHS [HL-52233] Funding Source: Medline
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Cytochrome P450 (CYP) enzyme 2J2, an epoxygenase predominantly expressed in the heart, metabolizes arachidonic acid to biologically active eicosanoids. One of the CYP2J2 products, 11,12-epoxyeicosatrienoic acid, has several vasoprotective effects. A frequent promoter polymorphism of CYP2J2 decreases gene expression and is associated with coronary artery disease. This association supports the vascular protective role of CYP-derived eicosanoids in cardiovascular disease.
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